Encyclopedia
All the peptides
28 entries. INCI first, mechanism second, hype nowhere. Filter by the conversation the molecule is actually in.
28 entries
GHK-Cu
Copper Tripeptide-1
Gly-His-Lys · Cu²⁺
A naturally occurring copper-binding tripeptide. Isolated from human plasma in 1973, GHK-Cu is the peptide ION BLUE formulates at a disclosed 0.10% — a signal, not a bigger number.
GHK
Tripeptide-1
Gly-His-Lys
The copper-free tripeptide. Same backbone as GHK-Cu, without the metal. Useful for understanding what the ligand does versus what the ion does.
Matrixyl
Palmitoyl Pentapeptide-4
Pal-Lys-Thr-Thr-Lys-Ser
A palmitoylated fragment of procollagen I. One of the most studied signal peptides in cosmetics — the template for “tell fibroblasts to write matrix.”
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-1
Pal-Gly-His-Lys
GHK with a palmitoyl tail and no copper. Often paired with palmitoyl tetrapeptide-7 as “Matrixyl 3000.”
Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7
Pal-Gly-Gln-Pro-Arg
A lipidated fragment related to immunoglobulin G. Studied for downstream inflammatory signaling in dermal cells, usually as half of Matrixyl 3000.
Syn-Coll
Palmitoyl Tripeptide-5
Pal-Lys-Val-Lys
A palmitoylated tripeptide designed as a thrombospondin-1 mimic — a different door into collagen I synthesis than Pal-KTTKS.
Matrixyl Synthe’6
Palmitoyl Tripeptide-38
Pal-Lys-Met(O₂)-Lys
A matrikine-inspired tripeptide studied for several matrix proteins — collagen I, III, IV, fibronectin, hyaluronic acid, and laminin-5 — in supplier models.
Argireline
Acetyl Hexapeptide-8
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂
A SNAP-25 fragment analogue. Designed to compete with the SNARE complex that releases acetylcholine at the neuromuscular junction — the “expression-line” peptide.
SNAP-8
Acetyl Octapeptide-3
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
An elongated Argireline: eight residues instead of six, still aimed at the SNARE / SNAP-25 conversation.
Leuphasyl
Pentapeptide-18
Tyr-D-Ala-Gly-Phe-Leu
An enkephalin-inspired pentapeptide. Instead of SNARE competition, it is studied for a more upstream, agonist-style modulation of neurotransmitter release.
SYN-AKE
Dipeptide Diaminobutyroyl Benzylamide Diacetate
β-Ala-Pro-Dab-NH-Bzl (mimetic)
A tripeptide-mimetic inspired by waglerin-1, a peptide from Temple viper venom that targets the nicotinic acetylcholine receptor.
Progeline
Trifluoroacetyl Tripeptide-2
TFA-Val-Tyr-Val
A tripeptide studied for progerin-related and elastase-related aging pathways — a different “aging clock” than collagen-fragment peptides.
Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5
Ac-β-Ala-His-Ser-His
A tetrapeptide used around the eye for the appearance of puffiness — studied for anti-edema and glycation-related pathways in supplier work.
Calmosensine
Acetyl Dipeptide-1 Cetyl Ester
Ac-Tyr-Arg-cetyl ester
A lipophilic dipeptide studied as a “messenger of well-being” — met-enkephalin related — for the appearance of tightness and discomfort.
Melanostatine
Nonapeptide-1
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val
A biomimetic antagonist of α-MSH signaling — studied for reducing melanin synthesis rather than destroying melanocytes.
Tetrapeptide-30
Tetrapeptide-30
Pro-Lys-Glu-Lys
A tetrapeptide studied for evening the appearance of tone, including UV-related pigmentation models, with an anti-inflammatory angle.
Hexapeptide-9
Hexapeptide-9
Gly-Pro-Gln-Gly-Pro-Gln
A collagen-like hexapeptide studied for dermal-epidermal junction support — collagen IV, XVII, laminin — more “anchoring” than “plumping.”
Hexapeptide-11
Hexapeptide-11
Phe-Val-Ala-Pro-Phe-Pro
A yeast-derived hexapeptide studied for firmness and for proteasome / antioxidant gene programs — an aging-maintenance signal rather than a matrikine.
sh-Oligopeptide-1
sh-Oligopeptide-1
53-aa EGF sequence (recombinant)
A recombinant epidermal-growth-factor sequence. A growth-factor protein, not a short signal peptide — and a reminder that “peptide” on a label can mean very different molecules.
Biotinoyl Tripeptide-1
Biotinoyl Tripeptide-1
Biotin-Gly-His-Lys
GHK with a biotin (vitamin B7) cap, used in lash and hair-anchor formulas. Same backbone, different destination.
Myristoyl Pentapeptide-17
Myristoyl Pentapeptide-17
Myr-Lys-Leu-Ala-Lys-Lys
A myristoylated pentapeptide used in lash-conditioning formulas, often alongside myristoyl hexapeptide-16.
Tetrapeptide-21
Tetrapeptide-21
Gly-Glu-Lys-Gly
A collagen-fragment tetrapeptide (GEKG) studied for collagen I, hyaluronic acid, and fibronectin — a smaller cousin of Pal-KTTKS, without a lipid tail in the parent INCI.
Palmitoyl Hexapeptide-12
Palmitoyl Hexapeptide-12
Pal-Val-Gly-Val-Ala-Pro-Gly
A palmitoylated elastin fragment (VGVAPG). Aimed at elastin biology rather than collagen I — a useful contrast in the signal-peptide family.
Caprooyl Tetrapeptide-3
Caprooyl Tetrapeptide-3
Caprooyl-Lys-Gly-His-Lys
A lipidated tetrapeptide related to IgG / GHK themes, studied for DEJ proteins (collagen VII, laminin, fibronectin) in supplier work.
Dipeptide-2
Dipeptide-2
Val-Trp
A valine-tryptophan dipeptide used in periocular blends (classically with hesperidin and palmitoyl tetrapeptide-7) for the appearance of bags and dark circles.
Acetyl Tetrapeptide-2
Acetyl Tetrapeptide-2
Ac-Glu-Gln-Arg-Lys
A thymopoietin-inspired tetrapeptide studied for immune-skin aging — the idea that skin’s immune tone declines with age and can be spoken to.
Palmitoyl Tetrapeptide-20
Palmitoyl Tetrapeptide-20
Pal-His-D-Phe-Arg-Trp (related agonist motif)
A lipidated tetrapeptide studied for hair-greying appearance via MC1R / melanocortin signaling in the follicle — the inverse of a brightening antagonist.
Palmitoyl Tripeptide-8
Palmitoyl Tripeptide-8
Pal-His-D-Phe-Arg
A lipidated tripeptide inspired by α-MSH’s anti-inflammatory face — used to calm the look of reactive, neurogenic inflammation.